Who We Are
Gifford Bioscience is a preclinical and discovery stage Contract Research Organisation (CRO). We specialize in receptor pharmacology and occupancy studies for neuroscience, oncology and metabolic diseases.
We determine receptor density, binding parameters, efficacy and receptor occupancy for your test compounds.
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Recurring customers
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US customers
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European customers
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PhD level scientists
Our PhD level scientists are experts in gold-standard radiometric methods and in advanced label-free, kinetic affinity techniques. Our customized assays use human tissue, animal tissues, cultured cells, membranes and recombinant proteins. We work with leading pharma, biotech and university researchers, worldwide.
Determination of receptor affinities and ligand binding parameters for test compounds in a tissue homogenate or cell preparation.
Imaging the distribution of a labeled test drug in tissue sections. Quantification of ligand binding in regions of interest.
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Measurement of the degree to which a test compound engages its target receptor in tissues or in an animal.
Measurement of a compounds transport into cells or efflux from cells. Determination of a compound’s potency and efficacy.
Kinetic, label-free measurement of a drug’s affinity for its receptor using Surface Plasmon Resonance (SPR).
Measurement of second messenger levels resulting from ligand binding. Determination of potency and efficacy of compounds and identification of agonists and antagonists.
Additional Services
as part of a core receptor pharmacology study
Ancillary Services
as part of a core receptor pharmacology study
Custom Radiolabeling
Human and Animal Tissue
ELISAs
Cell Culture & Transfections
Latest News
Radioligand Binding vs SPR: Choosing the Right Binding Assay for Drug Discovery
What is the difference between radioligand binding and SPR? Radioligand binding uses radiolabelled ligands to...
Serotonin (5-HT) Receptors: Classification, Signalling, Disease Roles. How to Characterise Them with Radioligand Binding and Functional Assays
5-Hydroxytryptamine (5-HT; serotonin) was first identified in the gastrointestinal tract and subsequently...
How MAO A Inhibitors Reshape Dopamine Balance
Case study: Showing how MAO A inhibitors reshape dopamine balance Context, CNS and addiction biology Service area,...
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