Who We Are
Gifford Bioscience is a preclinical and discovery stage Contract Research Organisation (CRO). We specialize in receptor pharmacology and occupancy studies for neuroscience, oncology and metabolic diseases.
We determine receptor density, binding parameters, efficacy and receptor occupancy for your test compounds.
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Recurring customers
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US customers
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European customers
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PhD level scientists
Our PhD level scientists are experts in gold-standard radiometric methods and in advanced label-free, kinetic affinity techniques. Our customized assays use human tissue, animal tissues, cultured cells, membranes and recombinant proteins. We work with leading pharma, biotech and university researchers, worldwide.
Determination of receptor affinities and ligand binding parameters for test compounds in a tissue homogenate or cell preparation.
Imaging the distribution of a labeled test drug in tissue sections. Quantification of ligand binding in regions of interest.
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Measurement of the degree to which a test compound engages its target receptor in tissues or in an animal.
Measurement of a compounds transport into cells or efflux from cells. Determination of a compound’s potency and efficacy.
Kinetic, label-free measurement of a drug’s affinity for its receptor using Surface Plasmon Resonance (SPR).
Measurement of second messenger levels resulting from ligand binding. Determination of potency and efficacy of compounds and identification of agonists and antagonists.
Additional Services
as part of a core receptor pharmacology study
Ancillary Services
as part of a core receptor pharmacology study
Custom Radiolabeling
Human and Animal Tissue
ELISAs
Cell Culture & Transfections
Latest News
The Endogenous Tissue Advantage: Why Multi-Receptor Expression in Native Systems Matters for Drug Discovery
Why does native tissue pharmacology matter? Native tissue preserves physiological receptor density, multi-receptor...
Neurotransmitter Release Assays: A Pharmacological Window into Neuropsychiatric Drug Mechanisms
What is a neurotransmitter release assay? A neurotransmitter release assay measures the ability of compounds to...
Ex Vivo Receptor Occupancy: Bridging In Vitro Potency to In Vivo Drug Action
What is ex vivo receptor occupancy? Ex vivo receptor occupancy quantifies the percentage of target receptors...
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